????? ????? ???? ????? ?????? ???????? ?? ????? ??????? ????????Tadalafil is fourteen-fold extra potent for PDE5 than for PDE11A1 and 40-fold more strong for PDE5 than for PDE11A4, two with the four recognized forms of PDE11. PDE11 can be an enzyme located in human prostate, testes, skeletal muscle mass As well as in other tissues. In vitro, tadal